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Medical Physics and Clinical Engineering: working with clinical, academic and industrial colleagues, we improve healthcare by helping people understand about diagnosing and treating patients. We do this through science, engineering and physics.
Who we are
The Department of Medical Physics and Clinical Engineering is a joint venture between the Royal Liverpool University Hospital and the University of Liverpool. Set up in 1971, it moved to the newly built Royal Liverpool University Hospital in 1978 where it has remained ever since.
What we do
The department operates a Quality Management System (BS EN ISO 9001 and EN ISO 13485) for all of its activities which include:
Clinical Measurement Services
Research and Development
- Medical instrumentation
- Signal and image processing
- Clinical measurement
- Expert systems
- Safety of Medical Electrical Equipment
- Safety of Medical Electrical Systems
Medical Statistics, Refresher and Intermediate
Undergraduate and Postgraduate Teaching
- MSc Clinical Science (Medical Physics)
- MSc Medical Physics and Clinical Engineering (IPEM accredited)
- Vocational training for STP Healthcare Scientists in both Medical Physics and Clinical Engineering
The department consists of 18 staff offering a range of clinical measurement services to the Royal Liverpool Hospital and other hospital trusts in the North West of England. We are actively involved with research, development and innovation in a number of areas mainly, although not exclusively, in physiological measurement techniques.
The department is also home to the Merseyside Training Consortium which provides education and training to STP Trainee Healthcare Scientists. We currently have 19 trainees on rotation, contributing to clinical services and the research activities of the team as they work towards state registration.
Contact us on any of the numbers or email addresses listed below.
- Dr Christine Denby - Clinical Scientist (MRI) - 0151 706 4215 - Email Christine here
- Dr Antonio Eleuteri - Computer Scientist - 0151 706 4214 - Email Antonio here
- Dr Ayesh Alshukri - Computer Scientist - 0151 706 4225 - Email Ayesh her
- Waiel Elzamzami - Visual Electrophysiologist - 0151 706 4225 - Email Waiel here
- Prof Tony Fisher - Head of Department, Consultant Clinical Scientist - 0151 706 4212 - Email Tony here
- Prof David Groves - Consultant Medical Physicist - 0151 706 4217 - Email David here
- Laura Guido - Medical Secretary - 0151 706 4218 - Email Laura here
- Dr Richard Hagan - Consultant Clinical Scientist (Ophthalmology) - 0151 706 4216 - Email Richard Hagan
- Lynsey Holmes - Administrative Secretary - 0151 706 4202 - Email Lynsey here
- Deepthy Jayakrishnan - Visual electrophysiologist - 0151 706 4225 - Email Deepthy here
- Vicki Kennedy - Clinical Scientist - 0151 706 4208 - Email Vicki here
- Steve Lake - Consultant Clinical Scientist - 0151 706 4210 - Email Steve here
- Tristan Payne - Clinical Engineer - 0151 706 4223 - Email Tristan here
- Prof Azzam Taktak - Consultant Clinical Scientist - 0151 706 4214 - Email Azzam here
- Elaine Verdin - Medical Secretary - 0151 706 4218 - Email Elaine here
- Peter Watt - Design Engineer - 0151 706 4224 - Email Peter here
- 0151 706 4202
- Email us here
About the Medical Physics and Clinical Engineering Team
Dr Ayesh Alshukri
Ayesh has a BSc degree in Internet Computing, an MSc and Advanced Computer Science, and a PhD in Data Mining. He works on the data management team as an applications developer on the NIHR funded Individual risk-based Screening for Diabetic Retinopathy (ISDR) study. Under the supervision of Prof. Simon Harding and Prof. Tony Fisher. This team is responsible for processing, storage and management of large data sets from multiple sources within the NHS. This team also supports a Randomised Control Trial (RCT), a Risk Calculation Engine (RCE) and an Observational Cohort Studies (OCS) for the ISDR programme.
Dr Christine Denby
Christine has a PhD in Neuroimaging and has previously held research posts in Neuroimaging at the Universities of Liverpool and Manchester. She also provides research support to and collaborates with The Walton Centre. Her research interests and activities include cardiac electrophysiology, cardiac MRI, neuroimaging, structural and functional MRI, MRI physics and quality assurance and MR sequence development. Christine also lectures on the MSc Clinical Science – Medical Physics course in neuroanatomy, neurophysiology, clinical measurement, neuroimaging and functional MRI. She is also a regular reviewer for the British Journal of Radiology and is a member of the British Institute of Radiology.
Dr Antonio Eleuteri
Antonio has a Ph.D. in Applied Mathematics and Computer Science, with a specialisation in Probability and Statistics. He is also a Chartered Scientist and is a member of IPEM. His research interests focus on statistical learning theory, survival analysis, machine learning, pattern recognition, information geometry, stochastic processes, probability theory and graphical models; with applications to medicine and health care. In the past he has worked on statistical models applied to biology and astrophysics.
Waiel is a Visual Electrophysiologist. His duties involve supporting service delivery, research, teaching and training, mainly, but not exclusively, in visual electro-diagnostics. Waiel’s background is in bioengineering, with postgraduate clinical and research experience in Assistive Technology, Biomechanics and Electrophysiology. He has a special interest in research relating to the development of innovative medical/rehabilitative treatments and technologies, for people with long term medical conditions.
Prof Tony Fisher
Professor Tony Fisher is a Consultant Clinical Scientist and Head of Department, Director of the Merseyside Training Consortium in Medical Physics and Clinical Engineering and a Non-executive Director of the Academy for Healthcare Science (AHCS). HE was awarded an MBE in 2018 for his services to Healthcare Science. He is a Fellow of the Institute of Engineering and Technology (FIET CEng) , a Fellow of the Institute of Physics and Engineering in Medicine (FIPEM CSci), a Fellow of the Institute of Physics (CPhys) and a Fellow of the Academy for Healthcare Science He holds an MBBCH (Cardiff), an MD (Liverpool), an MSc in Biomedical Engineering (Surrey) and a PhD in Medical Physics and Bioengineering (Liverpool). His principal research interest is the analysis of electrophysiological signals.
Prof David Groves
David holds a BSc in Physics and a PhD in Bioengineering and is a member of the Institute of Physics and a Chartered Physicist. Following employment as a Medical Physicist in nuclear medicine, lecturer and senior lecturer in physics, computing and mathematics at a number of UK universities and as a senior scientist in the UK nuclear industry, David established a commercial medical technology company which he directed for 15 years. The company developed innovative 3D scanner technologies and commercial computer systems. His company developed, manufactured, installed and maintained ionising radiation free 3D body scanners, based on structured light technology, for clinical assessment of spinal deformities in the standing patient. The UK developed and manufactured scanners were licensed and sold in the USA, Europe and the former Eastern Block, winning 4 DTI awards. Additionally David established and co-directed a medical company offering clinical assessment and treatment of spinal disorders and sports injuries. Other commercial interests included provision of fully integrated computer services to the chemical manufacturing industry and consultancy to the AMDG group of companies. David retired from full time commercial activity in 1999 returning to the NHS in 2000 as director of research at the National Refractory Angina Centre (NRAC). At NRAC he helped establish the award winning NRAC angina management programme, developed novel ECG clinical assessments and non-surgical therapies in collaborations with a number of UK university based cardiology centres and commercial companies. He was appointed adjunct professor of healthcare and education technology at Hope University in 2008. He has recently moved to the RLBUHT Medical Physics and Clinical Engineering department to develop wider research collaborations between scientists and clinicians within and beyond the Trust. He is a member of the Japanese Soto Zen Buddhist Order and is on the executive and an active member of a multi-faith charity established to feed and support the homeless.
Laura joined MP&CE in 2016 as a Medical Secretary. She provides administrative support to the diagnostic audiology and vestibular testing service run by Vicki Kennedy.
Dr Richard Hagan
Richard is employed as a Consultant Clinical Scientist, who has worked for the NHS for more than 18 years, at present he is the Acting Head of Clinical Measurement which consists of Visual Electrophysiology and Audiology & Vestibular testing. His main interest is in visual electrophysiology. He is currently responsible for Adult and Paediatric Visual Electrophysiology services at RLUH & Alder Hey with around 100 consultant ophthalmologists referring in for his opinion. Richard has been involved in training Clinical Scientists for the last 12 years and has been an examiner for 5 years. Richard’s main research interests involve the mfERG both in large clinical studies with Prof Simon Harding and signal processing with Prof Tony Fisher. Other research interests are concerned with developing new technologies for the benefit of patient testing.
Lynsey joined the department in 2001 as Administrative Secretary. Her work includes organising short courses and conferences, assisting in upkeep of the department Quality Management System and work with the MTC and the University of Liverpool in recruiting and training STP Trainee Healthcare Scientists.
Deepthy is a Clinical Scientist in Visual Electrophysiology. She has extensive clinical experience of over 9 years at different departments in the UK including Nottingham University Hospitals NHS Trust and NHS Greater Glasgow and Clyde, both in adult and paediatric settings. Deepthy joined the department in 2013 as a Research Scientist. She has an MSc in Medical Physics from the University of Aberdeen.
Vicki is a Principal Clinical Scientist who joined the department in 1999. Her main areas of interest are Vestibular medicine and Auditory electrophysiology, but in the past she has also worked in Visual electrophysiology plus other areas of physiological measurement. Since 2013 Vicki has worked in vestibular function testing and diagnostic audiology service provision for the Merseyside region and Wirral, and has lead these services for the past 3 years. Currently Vicki sits on the committee of the British Society of Audiology specialist interest group for Balance. Vicki has a keen interest in teaching and training, and she lectures on Medical Physics Masters course, and is an assessor for Clinical Scientist registration final exams.
Steve is a Clinical Scientist with over 25 years experience of developing prototype ICT and embedded microprocessor solutions to help clinical professionals progress their innovative ideas. Projects have covered areas including electro-physiology of the eye, monitoring of radiation treatment of children with leukaemia, planning the fluid replacement for children suffering from severe burns, management of medical equipment, charting of vital signs during surgery and decision support for pre-op nurses preparing patients for surgery. Steve is a past examiner for the IPEM training scheme on ICT and a past ACS assessor.
Dr Tristan Payne
Tristan Payne (PhD) joined the department in 2013 as a trainee clinical scientist under the Scientist Training Programme (STP), having previously worked for 4 years in the NHS as a Medical Engineering Technician. In 2015, while continuing to complete his STP, he became a permanent member of staff with responsibilities including: facilitating Quality, co-ordinating Commercial Products and providing Computer Support. Tristan is developing the department’s ISO 13485- and ISO 9001-accredited Quality Management System, and also contributes to Research, Development and Innovation work in the department.
Prof Azzam Taktak
Prof. Taktak is a Consultant Clinical Scientist at the Royal Liverpool University Hospital and an Honorary Professor at the University of Liverpool. He is lead assessor at the National School for Healthcare Scientists. He is Chair of Course Accreditation Panel, a former Vice President and Director at the IPEM. His main research interests are mathematical and statistical modelling and the use of artificial intelligence and machine learning in medicine. To date he has published more than 75 peer-reviewed articles and edited 2 books, the first on Outcome Prediction in Cancer and the second on Clinical Engineering.
Elaine is the Medical Secretary to Dr Richard Hagan and is responsible for the keeping of patient records, database and general office duties.
Peter has an OTEC and HTEC in Electrical and Electronic Engineering. He has worked in medical electronics since 1977 and as designer in the Department since 1984, initially in association with Merseyside Innovation Centre and then with the charity Lasers for Life. Since then activities have included project development, solo and team roles; clinical physics support for Photo Dynamic Therapy laser; photography and video production.
Taktak, A. IPEM's Medical Physics and Engineering Conference (MPEC), Esher, Surrey, 13-14 September 2017.
Denby CE, Walsh E, Das H, Biswas S, Das K. Can fMRI reliably detect activation within the vicinity of an AVM? Poster. British Society of Neuroradiologists (BSNR) Annual Scientific Meeting. October 2016.
Sampson CJ, James M, Fisher AC and Harding SP, Cost-effectiveness of a risk-based screening programme for diabetic retinopathy: a modelling approach, Poster at ESDEC 2016 Manchester, 23 Jun 2016 - 25 Jun 2016
Amu Wang. Ayesh Alshukri. Mehrdad Mobayen-Rahni. Anthony Fisher. Deborah Broadbent. Duncan Appelbe. Simon Harding. Building a dynamic functional clinical data warehouse (CDW) for personalised health care - lessons from the Individualised Screening for Diabetic Retinopathy (ISDR) study. Poster at 26th Meeting of the European Association for the Study of Diabetes eye complications Study Group, Manchester, 23 Jun 2016 - 25 Jun 2016
Ayesh Alshukri. Building a dynamic functional clinical data warehouse (CDW) for personalised health care - lessons from the Individualised Screening for Diabetic Retinopathy (ISDR) study. Poster at 26th Meeting of the European Association for the Study of Diabetes eye complications (EASDec) Study Group, Manchester, 23 Jun 2016 - 25 Jun 2016
Simon Harding. Christopher Sampson. Christopher Cheyne. Deborah Broadbent. Amu Wang. Mehrdad Mobayen-Rahni. Ayesh Alshukri. Anthony Fisher. Jiten Vora. Marta Garcia Finana. 10 year observational study of patient related outcomes during expansion to full population coverage of a systematic diabetes eyecare programme - the Liverpool Diabetic Eye Study. In The association of research in vision and ophthalmology annual conference, Seattle, USA. 01 May 2016 - 05 May 2016. Investigative Ophthalmology & Visual Science. Association for Research in Vision and Ophthalmology (ARVO), 2016.
Biswas S, Denby CE, Das K. Does Cerebrovascular Reserve measured by CT Perfusion using Acetazolamide challenge predict future Stroke/TIA in Cerebro-vascular Steno-occlusive Disease. ASNR 54th Annual Meeting, May 2016.
S.P. Lake. Strategic Technological Assets Network (STAN): Managing Health Technology and the Technologists’ Role. Presentation at IPEM Meeting: Medical Technology of the Future, Manchester, January 2016.
Denby CE, Smith N. Performing QA in a Small MR Centre on a Budget: Evaluation and Future Direction. Oral Presentation at the IPEM Quality Assurance in Magnetic Resonance Conference, British Dental Association, London, November 2014.
Taktak, Azzam. Postgraduate Conference on Biomedical Engineering and Medical Physics (PGBiomed), IEEE EMBS UKRI Chapter, Warwick, 16-17 July 2014 (Invited Speaker)
G.R. Lightfoot. Does caffeine enhance the N1-P2 cortical response? Presentation at the XXIII Biennial Symposium of the IERASG, New Orleans, USA, June 2013.
G.R. Lightfoot. The effects of artefact rejection and Bayesian averaging on ABR efficiency. Presentation at the XXIII Biennial Symposium of the IERASG, New Orleans, USA, June 2013.
G.R. Lightfoot. Validation of objective measures of response quality and residual noise in two ABR systems. Presentation at the XXIII Biennial Symposium of the IERASG, New Orleans, USA, June 2013.
A.F.G. Taktak. Medical Physics & Engineering Conference (MPEC), Oxford, 10-12 September 2012.
A.F.G. Taktak. The 5th International Conference in Medical Signal and Information Processing (MEDSIP), IET, Liverpool, 5-6 July 2012.
A.F.G. Taktak. ARVO (The Association of Research in Vision and Ophthalmology) Annual Conference, Fort Lauderdale, Florida, 6-10 May 2012.
G.R. Lightfoot. A strategy for selecting the optimum artifact rejection level during diagnostic ABR testing. Presentation at the NHS 2012 conference, Como, Italy, June 2012.
G.R. Lightfoot. Do frequency specific chirps offer a quicker ABR assessment in newborns compared to tone pips? Poster presentation at the NHS 2012 conference, Como, Italy, June 2012.
- P. Lake. Providing scientific solutions as an online service: a SOAP solution
Bespoke Software in Medical Physics & Clinical Engineering
29th May 2012, UCL Institute of Child Health, London.
Kenawy N, Kalirai H, Sacco JJ, Lake SL, Heegaard S, Larsen AC, Finger PT, Milman T, Chin K, Mosci C, Lanza F, Moulin A, Schmitt CA, Caujolle JP, Maschi C, Marinkovic M, Taktak AF, Heimann H, Damato BE, Coupland SE.(doi: 10.1111/pcmr.12767) Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome. Pigment, Cell and Melanoma Research, Epub (2019)
Eleuteri, A.F.G. Taktak, S.E. Coupland, H. Heimann, H. Kalirai, B.E. Damato (doi: 10.1016/j.compbiomed.2018.09.024) Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model. Computers in Biology and Medicine, Epub(2018)
Farquhar, S. Thornton, S. E. Coupland, J. M. Coulson, J. J. Sacco, Y. Krishna, H. Heimann, A. Taktak, C. M. Cebulla, M. H. Abdul-Rahman, H. Kalirai (doi: 10.1002/cjp2.86) Patterns of BAP1 protein expression provide insight into prognostic significance and the biology of uveal melanoma The Journal of Pathology: Clinical Research, pp 1-13, Online publication (2017).
Angi, H. Kalirai, A. Taktak, R. Hussain, C. Groenewald, B. E. Damato, H. Heimann, S. E. Coupland (doi: 10.1136/bjophthalmol-2017-310361) Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach British Journal of Ophthalmology, 101, 8, 1143-1146(2017).
E. Coupland, A. Taktak, B. E. Damato (doi: 10.1001/jamaophthalmol.2017.1391) Incorporating clinical, histological, and genetic parameters for choroidal melanoma prognostication JAMA Ophthalmology, 135, 7, 818-819 (2017).
Walker, A., Patel, P., Rajwani, A., Groves, D., Denby, C., Kearney, L., Sapsford, R., Witte, K., Kearney, M. and Cubbon, R. (2016). Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction. Diabetes and Vascular Disease Research, 13(5), pp.331-340.
E. Medcalf, C. P. Johnson, A. Taktak, S. Grabherr (doi: 10.1007/s12024-016-9819-4)Variation in the anatomy of vertebral artery cervical loop segment - a potential predisposing factor for traumatic basal subarachnoid hemorrhage? Forensic Sci Med Pathol, 12 444-450 (2016).
Cubbon RM, Ruff N, Groves D, Eleuteri A, Denby C, Kearney L, Ali N, Walker AM, Jamil H, Gierula J, Gale CP, Batin PD, Nolan J, Shah AM, Fox KA, Sapsford RJ, Witte KK, Kearney MT. Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart, 2016; 102(3): 223-9.
S. W. DeParis, A. Taktak, A. Eleuteri, W. Enanoria, H. Heimann, S. E. Coupland, B. Damato External validation of the Liverpool uveal melanoma prognosticator online. Investigative Ophthalmology and Visual Science, 57, 6116 – 6122 (2016)
Denby C, Groves DG, Eleuteri A, Tsang HK, Leach A, Hammond C, Bridson JD, Fisher M, Elt M, Laflin R, Fisher AC.
Temporary sympathectomy in chronic refractory angina: a randomised, double-blind, placebo-controlled trial. British Journal of Pain, 2015; 9(3): 142-8.
Broadbent, D. M., Harding, S. P., Garcia-Finana, M., Fisher, A. C., Bennett, A., Appelbe, D. E., & Wang, A.
INTRODUCING PERSONALISED RISK BASED INTERVALS IN SCREENING FOR DIABETIC RETINOPATHY: THE ISDR STUDY. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2015, 25(3), E20-E21.
Harding, S. P., Eleuteri, A., Broadbent, D. M., Van der Hoek, M., Cheyne, C., Wang, A., . . . Fisher, A. C.
INDIVIDUALISED RISK-BASED SCREENING FOR DIABETIC RETINOPATHY – THE LIVERPOOL RISK CALCULATION ENGINE. In European Journal of Ophthalmology, 2015, June 26, Vol. 25 (pp. e7-e30). Turin. doi:10.5301/ejo.5000612
Harding, S. P., Eleuteri, A., Broadbent, D. M., van der Hoek, M., Cheyne, C. P., WANG, A., . . . Fisher, A. C.
Individualised risk-based screening for sight threatening diabetic retinopathy – the Liverpool Risk Calculation Engine (Conference Paper) (2015). Individualised risk-based screening for sight threatening diabetic retinopathy – the Liverpool Risk Calculation Engine. In Investigative Ophthalmology & Visual Science Vol. 56. Denver: Association for Research in Vision and Ophthalmology (ARVO). http://iovs.arvojournals.org/article.aspx?articleid=2331769
Appelbe, D., Broadbent, D. M., Mobayen Rahni, M., Eleuteri, A., Bennett, A., Moitt, T., . . . Harding, S. P.
Introducing personalised risk based intervals in screening for diabetic retinopathy: development, implementation and assessment of safety, cost-effectiveness and patient experience (ISDR): a case study in the use of automated systems in trials (Conference Paper 2015, November 16). Introducing personalised risk based intervals in screening for diabetic retinopathy: development, implementation and assessment of safety, cost-effectiveness and patient experience (ISDR): a case study in the use of automated systems in trials. In Trials Vol. 16. Glasgow. http://www.trialsjournal.com/content/16/S2/O59
Broadbent, D. M., Bennet, A., Appelbe, D., Wang, A., Van der Hoek, M., Fisher, A. C., & Harding, S. P.
Introducing personalised risk based intervals in screening for diabetic retinopathy: the ISDR study (Conference Paper 2015, June 26). Introducing personalised risk based intervals in screening for diabetic retinopathy: the ISDR study. In European Journal of Ophthalmology Vol. 25 (pp. e7-e30). Turin. doi:10.5301/ejo.5000612
S. Middle, S. E. Coupland, A. Taktak, V. Kidgell, J. Slupsky, A. R. Pettitt, K. J. Till
Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins, Experimental Hematology & Oncology, 4, 10 (2015)
R. Caines, A. Eleuteri, H. Kalirai, A.C. Fisher, H. Heimann, B.E. Damato, S.E. Coupland, A.F.G. Taktak
Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma, Molecular Vision, 21, 1-11 (2015)
Galarza M, Isaac C, Pellicer O, Mayes A, Broks P, Montaldi D, Denby C, Simeone F. Jazz, guitar, and neurosurgery: the Pat Martino case report. World Neurosurgery, 2014; 81(3-4): 651.
S.L. Lake, B.E. Damato, H. Kalirai, A.R. Dodson, A.F.G. Taktak, B.H. Lloyd, S.E. Coupland
Single nucleotide polymorphism array analysis of uveal melanomas reveals amplification of CNKSR3 is correlated with improved patient survival, American Journal of Pathology, 182, 3, 678-687
Ferm, I., Lightfoot, G., Stevens, J.
Comparison of ABR response size, test time and estimation of hearing threshold using frequency specific chirps and tone pips stimuli in newborns. Int J Audiol 2013 Jun;52(6):419-23.
Clinical Engineering. Eds: A. Taktak, P. Ganney, D. Long, P. White, Elsevier, Oxford (2013)
O.K. Idowu, Q. Ding, A.F.G. Taktak, C.R. Chandrasekar, Q. Yin
Clinical implication of pre-treatment Nuetrophil lymphocyte ratio in soft tissue sarcoma, Biomarkers, 17, 6, 539-544
F. Jmor, H. Kalirai, A.F.G. Taktak, B. E. Damato, S.E. Coupland
HSP-27 protein expression in uveal melanoma: correlation with survival, Acta Ophthalmologica, 90, 6, 534-539
A. Eleuteri, B.E. Damato, S.E. Coupland, A.F.G. Taktak
Enhancing survival prognostication in patients with choroidal melanoma by integrating pathologic, clinical and genetic predictors of metastasis. Int J Biomedical Engineering and Technology, 8,1, 18-35
A. Taktak, A. Eleuteri, A. Fisher, S.E. Coupland, B.E. Damato
A web-based tool for prognosis of patients with choroidal melanoma using accelerated failure time model. IOVS, ARVO E-Abstract, 5254
R.P. Hagan, K.A. Quinn, L. Milner, R. Robinson, A. Taktak, A. Fisher
Reproducibility of visual electrophysiology recordings between laboratories: the importance of regular calibration. IOVS, ARVO E-Abstract, 5707
Neary W, Lightfoot G.
Auditory neuropathy spectrum disorder: Examples of poor progress following cochlear implantation. Audiological Medicine, 2012; Early Online: 1–8.
A.C.Fisher, A.Eleuteri, D. Groves, C. Dewhurst
The Ornstein-Uhlenbeck third-order Gaussian process (OUGP) applied directly to the un-resampled heart rate variability (HRV) tachogram for detrending and low-pass filtering. Med Biol Eng Comput 50(7):737-42 (2012)
A. Eleuteri, A. Taktak
Support Vector Machines for Survival Regression. Lecture Notes in Computer Science, Springer (special issue CIBB2011), 2012
S.L. Lake, F. Jmor, J. Dopierala, A.F.G. Taktak, S.E. Coupland, B. E. Damato
Multiplex ligation-dependent probe amplification of conjunctival melanoma reveals common BRAF V600 gene mutation and gene copy number changes. Invest Ophthalmol Vis Sci, 52,85598-5604 (2011).
S.L. Lake, B.E. Damato, J. Dopierala, M.M. Baudo, A.F.G. Taktak, S.E. Coupland
Multiplex ligation-dependent probe amplification analysis of uveal melanoma with extraocular extension demonstrates heterogeneity of gross chromosomal abnormalities. Invest Ophthalmol Vis Sci, 52,8, 55595564 (2011).
B.E. Damato, A. Eleuteri, A.F.G. Taktak, S.E. Coupland
Estimating prognosis for survival after treatment of choroidal melanoma. Prog Retin Eye Res, 30,5, 285-295 (2011).
S. Harigopal, H.P. Satish, A.F.G. Taktak, K.W.Southern, N.J. Shaw
Oxygen saturation profiles in healthy preterm infants. Archives of Disease in Childhood Fetal and Neonatal Edition, 96,5, F339-F342 (2011).
M. Angi, B. Damato, H. Kalirai, A. Dodson, A. Taktak, S. Coupland
Immunohistochemical assessment of mitotic count in uveal melanoma. Acta Ophtalmologica, 89, e155-e160 (2011)
Campa C, Hagan R, Sahni JN, Brown MC, Beare NA, Heimann H, Harding SP.
Early Multifocal Electroretinogram Findings during Intravitreal Ranibizumab treatment for neovascular Age-related Macular Degeneration. Invest Ophthalmol Vis Sci Epub 2011 Feb 25.
Saeed MU, Noonan C, Hagan R, Brown M.
Relatively spared central multifocal electroretinogram responses in acute quinine toxicity. BMJ case rep. 2011 Jul 7.
Hagan RP, Fisher AC, Brown MC.
Investigation of the temporal properties of the retina using the m-sequence. Doc Ophthalmol. 2011 Oct 22 (Epub ahead of print).
J. Dopierala, B.E. Damato, S.L. Lake, A.F.G. Taktak, S.E. Coupland
Heterogeneity of genetic abnormalities in uveal melanoma assessed by multiplex ligation-dependent probe amplification. Invest Ophthalmol Vis Sci. 51,10, 4898-4905 (2010).
S.L. Lake, S.E. Coupland, A.F.G. Taktak and B.E. Damato.
Whole genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma. Invest Ophthalmol Vis Sci. 51,10, 4884-4891 (2010).
R.N.G. Naguib, A.F.G. Taktak
Decision support in Medicine. Int J Biomedical Engineering and Technology; Editorial. 3, 3/4, 209-211 (2010)
D.M.Broadbent, A.Stangos, A.C.Fisher, A.Eleuteri, N.Collaer, S.P.Harding.
An expert system for the risk estimation of the presence of sight threatening diabetic retinopathy and its implementation as an Internet resource. Medical Ophthalmological Society UK proceedings, 2010.
Hagan RP, Small A, Fisher AC, Brown MC.
Can central hexagon peak latency provide a clue to fixation with the mfERG. Doc Ophthalmol. 2010 Apr:120(2):159-64. 2009 Dec 1 [EPUB]
Raja V, Kumar A, Durnian J, Hagan R, Buxton N, Newman W.
The role of visual evoked potentials in the management of hemispheric arachnoid cyst compressing the posterior visual pathways. JAAPOS 2010 Feb:14(1):85-7. Epub 2009 Dec 31.
A. C. Fisher, S. P. Lake, I. P. Cunningham, A. Chandna
Web-StrabNet: a web-based expert system for the differential diagnosis of vertical strabismus Computational and Mathematical Methods in Medicine, Vol. 11, No. 1, March 2010, 89-97
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