Medical Physics and Clinical Engineering: working with clinical, academic and industrial colleagues, we improve healthcare by helping people understand about diagnosing and treating patients. We do this through science, engineering and physics.
The Department of Medical Physics and Clinical Engineering is a joint venture between the Royal Liverpool University Hospital and the University of Liverpool. Set up in 1971, it moved to the newly built Royal Liverpool University Hospital in 1978 where it has remained ever since.
The department operates a Quality Management System for all of its activities which include:
The department consists of a number of staff offering a range of clinical measurement services to the Liverpool University Hospitals NHS Foundation Trust and other hospital trusts in the North West of England. We are actively involved with research, development and innovation in a number of areas mainly, although not exclusively, in physiological measurement techniques.
The department is also home to the Merseyside Training Consortium which provides education and training to STP Trainee Healthcare Scientists. We have a number of trainees on rotation, contributing to clinical services and the research activities of the team as they work towards state registration.
Contact us on any of the numbers or email addresses listed below.
Alex first joined the department in 2014 as a trainee clinical scientist under the Scientist Training Programme (STP) in clinical engineering. After qualifying as a Clinical Scientist, Alex worked in Rehabilitation Engineering (Leeds Teaching Hospitals NHS Trust) and then in Specialist Scientific Physiological Services (Sheffield Teaching Hospitals NHS Foundation Trust) before returning to the department as a full-time member of staff. She now works across our Clinical Measurement services; Vestibular Testing and Auditory Electrophysiology, and Visual Electrophysiology, and is involved in the clinical engineering training. She has a BSc in Physics (University of Leicester) and an MSc in Clinical Engineering (Kings College London).
Dr Christine Denby
Christine has a PhD in Neuroimaging and has previously held neuroimaging posts at the Universities of Liverpool and Manchester. She also collaborates with The Walton Centre & Countess of Chester Foundation Trusts. Her research interests and activities include cardiac electrophysiology, cardiac MRI and CT in coronary artery disease, heart failure and angina. She also has an interest in structural and functional neuroimaging, MRI physics and quality assurance and MR sequence development. Christine also lectures on the MSc Clinical Science – Medical Physics course in neuroanatomy, neurophysiology, clinical measurement, neuroimaging, functional MRI, MRI physics and clinical imaging applications. She is also a regular reviewer for the British Journal of Radiology and is a member of the British Institute of Radiology.
Dr Antonio Eleuteri
Antonio has a Ph.D. in Applied Mathematics and Computer Science, with a specialisation in Probability and Statistics. He is also a Chartered Scientist and is a member of IPEM. His research interests focus on statistical learning theory, survival analysis, machine learning, pattern recognition, information geometry, stochastic processes, probability theory and graphical models; with applications to medicine and health care. In the past he has worked on statistical models applied to biology and astrophysics.
Waiel is a Visual Electrophysiologist. His duties involve supporting service delivery, research, teaching and training, mainly, but not exclusively, in visual electro-diagnostics. Waiel’s background is in bioengineering, with postgraduate clinical and research experience in Assistive Technology, Biomechanics and Electrophysiology. He has a special interest in research relating to the development of innovative medical/rehabilitative treatments and technologies, for people with long term medical conditions.
Prof Tony Fisher
Professor Tony Fisher is a Consultant Clinical Scientist and Head of Department, Director of the Merseyside Training Consortium in Medical Physics and Clinical Engineering and a Non-executive Director of the Academy for Healthcare Science (AHCS). HE was awarded an MBE in 2018 for his services to Healthcare Science. He is a Fellow of the Institute of Engineering and Technology (FIET CEng) , a Fellow of the Institute of Physics and Engineering in Medicine (FIPEM CSci), a Fellow of the Institute of Physics (CPhys) and a Fellow of the Academy for Healthcare Science He holds an MBBCH (Cardiff), an MD (Liverpool), an MSc in Biomedical Engineering (Surrey) and a PhD in Medical Physics and Bioengineering (Liverpool). His principal research interest is the analysis of electrophysiological signals.
Laura joined MP&CE in 2016 as a Medical Secretary. She provides administrative support to the diagnostic audiology and vestibular testing service run by Vicki Kennedy.
Dr Richard Hagan
Richard is a Chartered Engineer (IPEM) and has been employed as a Consultant Healthcare Scientist since 2010. He has over 20 years’ experience in visual electrophysiology. He has led the visual electrophysiology service since 2009, taking over from the founder of Clinical Engineering Dr Malcolm Brown and this service has continued to be one of the main centres for visual electrophysiology testing in the North West region with more than 10 trusts referring their patients for testing. There is a paediatric arm to the service which is performed at Alder Hey. In 2013 Richard took over the duties of the head of Clinical Measurement when Dr Guy Lightfoot retired.
He has been involved with training medical physicists and clinical engineers for more than 15 years and has been an end point examiner (to obtain state registration) for close to 10 years, firstly acting on behalf of IPEM for ACS and latterly for IPEM on behalf of the National School of Healthcare Science at the OSFA exams. He has provided supervision for numerous MSc projects and 2 PhDs to date.
Research is of great interest to Richard and he has successfully investigated new techniques prior to clinical adaptation. He has collaborated in large clinical trials with Professor Simon Harding, ensuring high quality visual electrophysiology data can be produced along with other clinical outcomes. Other collaborations are underway with Prof Racheal Williams and Dr Victoria Kearns at the university, looking at developing new diagnostic devices and basic science underpinning the ERG. He has collaborated with Mr Peter Watt in developing bespoke solutions for patient testing across all 3 labs over a number of years. Other collaborations include post process signal processing with Tony Fisher, which have resulted in several publications and perhaps a dozen national and/or international presentations.
Lynsey joined the department in 2001 as Administrative Secretary. Her work includes organising short courses and conferences, assisting in upkeep of the department Quality Management System and work with the MTC and the University of Liverpool in recruiting and training STP Trainee Healthcare Scientists.
Deepthy is a Clinical Scientist in Clinical Measurement. She joined the department in 2013 as a Research Scientist. Her main area of interest is Visual Electrophysiology, both adult and paediatric. She also works in Audiology and Vestibular Balance testing and is involved in the training of Healthcare Scientists. She has extensive clinical experience of over 13 years working at different departments in the UK including Nottingham University Hospitals NHS Trust and NHS Greater Glasgow and Clyde.
Vicki is a Principal Clinical Scientist who joined the department in 1999. Her main areas of interest are Vestibular medicine and Auditory electrophysiology, but in the past she has also worked in Visual electrophysiology plus other areas of physiological measurement. Since 2013 Vicki has worked in vestibular function testing and diagnostic audiology service provision for the Merseyside region and Wirral, and has lead these services for the past 3 years. Currently Vicki sits on the committee of the British Society of Audiology specialist interest group for Balance. Vicki has a keen interest in teaching and training, and she lectures on Medical Physics Masters course, and is an assessor for Clinical Scientist registration final exams.
Ste is a Clinical Scientist with 35 years experience of developing prototype ICT and embedded microprocessor solutions to help clinical professionals progress their innovative ideas. Projects have covered areas including electro-physiology of the eye, monitoring of radiation treatment of children with leukaemia, planning the fluid replacement for children suffering from severe burns, management of medical equipment, charting of vital signs during surgery and decision support for pre-op nurses preparing patients for surgery. Ste is a past examiner for the IPEM training scheme on ICT and a past ACS assessor.
Dr Tristan Payne
Tristan Payne (PhD) joined the department in 2013 as a trainee clinical scientist under the Scientist Training Programme (STP), having previously worked for 4 years in the NHS as a Medical Engineering Technician. In 2015, while continuing to complete his STP, he became a permanent member of staff with responsibilities including: facilitating Quality, co-ordinating Commercial Products and providing Computer Support. Tristan maintains the department’s ISO 13485-certified Quality Management System to support the manufacture and distribution of CE marked medical devices such as the Silver Thread ERG Electrode, is developing quality around medical device development activities, and contributes to Research, Development and Innovation work in the department.
Prof Azzam Taktak
Prof. Taktak is a Consultant Clinical Scientist at the Royal Liverpool University Hospital and an Honorary Professor at the University of Liverpool. He is lead assessor at the National School for Healthcare Scientists. He is Chair of Course Accreditation Panel, a former Vice President and Director at the IPEM. His main research interests are mathematical and statistical modelling and the use of artificial intelligence and machine learning in medicine. To date he has published more than 75 peer-reviewed articles and edited 2 books, the first on Outcome Prediction in Cancer and the second on Clinical Engineering.
Elaine is the Medical Secretary to Dr Richard Hagan and is responsible for the keeping of patient records, database and general office duties.
Peter is a design engineer and has an OTEC and HTEC in Electrical and Electronic Engineering. Peter has worked in medical electronics since 1977 and as designer in the department, since 1984. Innovative activity has included award winning and commercially successful team designs both internal and external to the department.
Chen, Y., Denby, C., Kreilkamp, B. A. K., Bracewell, M., Das, K., Fallon, N., Pegg, E., Mohanraj, R., Marson, A. G., Keller, S. S. Automated white matter tractography in genetic generalized epilepsy. Presentation at American Epilepsy Society, Baltimore, USA. December 2019.
Brownhill, D., Chen, Y., Kreilkamp, B. A. K., Denby, C., Bracewell, M., Das, K., Marson, T., Keller, S. S. Automatic subcortical segmentation and volume estimation of 2D T1-weighted MRI in epilepsy. Presentation at American Epilepsy Society, Baltimore, USA. December 2019.
Chen, Y., Denby, C., Kreilkamp, B. A. K., Bracewell, M., Das, K., Fallon, N., Pegg, E., Mohanraj, R., Marson, A. G., Keller, S. S. Probabilistic mapping of thalamic nuclei atrophy in idiopathic generalised epilepsy. Presentation at International Epilepsy Congress (IEC), Bangkok, Thailand. June 2019.
Chen, Y., Denby, C., Kreilkamp, B. A. K., Bracewell, M., Das, K., Marson, A. G., Keller, S. S. Altered large-scale resting-state functional networks in idiopathic generalised epilepsy. Presentation at European Congress for Epileptology (ECE), Vienna, Austria. August 2018.
Taktak, A. IPEM's Medical Physics and Engineering Conference (MPEC), Esher, Surrey, 13-14 September 2017.
Denby CE, Walsh E, Das H, Biswas S, Das K. Can fMRI reliably detect activation within the vicinity of an AVM? Poster at British Society of Neuroradiologists (BSNR) Annual Scientific Meeting. October 2016.
Sampson CJ, James M, Fisher AC and Harding SP. Cost-effectiveness of a risk-based screening programme for diabetic retinopathy: a modelling approach. Poster at ESDEC 2016 Manchester, 23 Jun 2016 - 25 Jun 2016
Amu Wang. Ayesh Alshukri. Mehrdad Mobayen-Rahni. Anthony Fisher. Deborah Broadbent. Duncan Appelbe. Simon Harding. Building a dynamic functional clinical data warehouse (CDW) for personalised health care - lessons from the Individualised Screening for Diabetic Retinopathy (ISDR) study. Poster at 26th Meeting of the European Association for the Study of Diabetes eye complications Study Group, Manchester, 23 Jun 2016 - 25 Jun 2016
Ayesh Alshukri. Building a dynamic functional clinical data warehouse (CDW) for personalised health care - lessons from the Individualised Screening for Diabetic Retinopathy (ISDR) study. Poster at 26th Meeting of the European Association for the Study of Diabetes eye complications (EASDec) Study Group, Manchester, 23 Jun 2016 - 25 Jun 2016
Simon Harding. Christopher Sampson. Christopher Cheyne. Deborah Broadbent. Amu Wang. Mehrdad Mobayen-Rahni. Ayesh Alshukri. Anthony Fisher. Jiten Vora. Marta Garcia Finana. 10 year observational study of patient related outcomes during expansion to full population coverage of a systematic diabetes eyecare programme - the Liverpool Diabetic Eye Study. Presentation at the association of research in vision and ophthalmology annual conference, Seattle, USA. 01 May 2016 - 05 May 2016.
Biswas S, Denby CE, Das K. Does Cerebrovascular Reserve measured by CT Perfusion using Acetazolamide challenge predict future Stroke/TIA in Cerebro-vascular Steno-occlusive Disease. Presentation at ASNR 54th Annual Meeting, May 2016.
S.P. Lake. Strategic Technological Assets Network (STAN): Managing Health Technology and the Technologists’ Role. Presentation at IPEM Meeting: Medical Technology of the Future, Manchester, January 2016.
Harding, S. P., Eleuteri, A., Broadbent, D. M., Van der Hoek, M., Cheyne, C., Wang, A., . . . Fisher, A. C., Individualised risk-based screening for diabetic retinopathy – the Liverpool risk calculation engine. Presentation at the Meeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec), Turin, June 26-28 2015
Harding, S. P., Eleuteri, A., Broadbent, D. M., van der Hoek, M., Cheyne, C. P., WANG, A., . . . Fisher, A. C., Individualised risk-based screening for sight threatening diabetic retinopathy – the Liverpool Risk Calculation Engine. Presentation at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, Denver, June 2015.
Appelbe, D., Broadbent, D. M., Mobayen Rahni, M., Eleuteri, A., Bennett, A., Moitt, T., . . . Harding, S. P., Introducing personalised risk based intervals in screening for diabetic retinopathy: development, implementation and assessment of safety, cost-effectiveness and patient experience (ISDR): a case study in the use of automated systems in trials Presentation at the International Clinical Trials Methodology Conference, Glasgow, November 2015
Broadbent, D. M., Bennet, A., Appelbe, D., Wang, A., Van der Hoek, M., Fisher, A. C., & Harding, S. P., Introducing personalised risk based intervals in screening for diabetic retinopathy: the ISDR study. Presentation at the Meeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec), Turin, June 26-28 2015
Denby CE, Smith N. Performing QA in a Small MR Centre on a Budget: Evaluation and Future Direction. Presentation at the IPEM Quality Assurance in Magnetic Resonance Conference, British Dental Association, London, November 2014.
Taktak, Azzam. Postgraduate Conference on Biomedical Engineering and Medical Physics (PGBiomed), IEEE EMBS UKRI Chapter, Warwick, 16-17 July 2014 (Invited Speaker)
G.R. Lightfoot. Does caffeine enhance the N1-P2 cortical response? Presentation at the XXIII Biennial Symposium of the IERASG, New Orleans, USA, June 2013.
G.R. Lightfoot. The effects of artefact rejection and Bayesian averaging on ABR efficiency. Presentation at the XXIII Biennial Symposium of the IERASG, New Orleans, USA, June 2013.
G.R. Lightfoot. Validation of objective measures of response quality and residual noise in two ABR systems. Presentation at the XXIII Biennial Symposium of the IERASG, New Orleans, USA, June 2013.
Taktak, A. Eleuteri, A. Fisher, S.E. Coupland, B.E. Damato, A web-based tool for prognosis of patients with choroidal melanoma using accelerated failure time model. Presentation at ARVO (The Association of Research in Vision and Ophthalmology) Annual Conference, Fort Lauderdale, Florida,6-10 May 2012.
A.F.G. Taktak. Medical Physics & Engineering Conference (MPEC), Oxford, 10-12 September 2012.
A.F.G. Taktak. The 5th International Conference in Medical Signal and Information Processing (MEDSIP), IET, Liverpool, 5-6 July 2012.
G.R. Lightfoot. A strategy for selecting the optimum artifact rejection level during diagnostic ABR testing. Presentation at the NHS 2012 conference, Como, Italy, June 2012.
G.R. Lightfoot. Do frequency specific chirps offer a quicker ABR assessment in newborns compared to tone pips? Poster presentation at the NHS 2012 conference, Como, Italy, June 2012.
R.P. Hagan, K.A. Quinn, L. Milner, R. Robinson, A. Taktak, A. Fisher. Reproducibility of visual electrophysiology recordings between laboratories: the importance of regular calibration. Presentation at ARVO (The Association of Research in Vision and Ophthalmology) Annual Conference, Fort Lauderdale, Florida, 6-10 May 2012.
S.P. Lake. Providing scientific solutions as an online service: a SOAP solution, Bespoke Software in Medical Physics & Clinical Engineering, 29th May 2012, UCL Institute of Child Health, London.
D.M.Broadbent, A.Stangos, A.C.Fisher, A.Eleuteri, N.Collaer, S.P.Harding. An expert system for the risk estimation of the presence of sight threatening diabetic retinopathy and its implementation as an Internet resource. Presentation at Medical Ophthalmological Society UK proceedings, 2010.
A.F.G. Taktak, P. Ganney, D. Long, P. White (2020) Clinical Engineering: A Handbook for Clinical and Biomedical Engineers(2nd ed.), Elsevier, ISBN: 9780081026946
Hagan R (2020). ‘Visual Electrophysiology Measurement’, in Taktak, AFG et al (2nd ed.) Clinical Engineering-A Handbook for Clinical and Biomedical Engineers. Elsevier 321-341 ISBN: 9780081026946
Denby, C. E., Chatterjee, K., Pullicino, R., Lane, S., Radon, M. R., & Das, K. V. (2020). Is four-dimensional CT angiography as effective as digital subtraction angiography in the detection of the underlying causes of intracerebral haemorrhage: A systematic review. Neuroradiology, 62(3), 273–281. https://doi.org/10.1007/s00234-019-02349-z
Makuloluwa, A. K., Dodeja, R., Georgiou, M., Gonzalez-Martin, J., Hagan, R., Madhusudhan, S., & Michaelides, M. (2020). Oliver McFarlane syndrome and choroidal neovascularisation: A case report. Ophthalmic Genetics, 41(5), 451–456. https://doi.org/10.1080/13816810.2020.1783689
Kenawy, N., Kalirai, H., Sacco, J. J., Lake, S. L., Heegaard, S., Larsen, A.-C., Finger, P. T., Milman, T., Chin, K., Mosci, C., Lanza, F., Moulin, A., Schmitt, C. A., Caujolle, J. P., Maschi, C., Marinkovic, M., Taktak, A. F., Heimann, H., Damato, B. E., & Coupland, S. E. (2019). Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome. Pigment Cell & Melanoma Research, 32(4), 564–575. https://doi.org/10.1111/pcmr.12767
Eleuteri, A., Taktak, A. F. G., Coupland, S. E., Heimann, H., Kalirai, H., & Damato, B. (2018). Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model. Computers in Biology and Medicine, 102, 151–156. https://doi.org/10.1016/j.compbiomed.2018.09.024
Angi, M., Kalirai, H., Taktak, A., Hussain, R., Groenewald, C., Damato, B. E., Heimann, H., & Coupland, S. E. (2017). Prognostic biopsy of choroidal melanoma: An optimised surgical and laboratory approach. British Journal of Ophthalmology, 101(8), 1143–1146. https://doi.org/10.1136/bjophthalmol-2017-310361
Coupland, S. E., Taktak, A., & Damato, B. (2017). Incorporating Clinical, Histological, and Genetic Parameters for Choroidal Melanoma Prognostication. JAMA Ophthalmology, 135(7), 818–819. https://doi.org/10.1001/jamaophthalmol.2017.1391
Eleuteri, A., Fisher, A. C., Broadbent, D. M., García-Fiñana, M., Cheyne, C. P., Wang, A., Stratton, I. M., Gabbay, M., Seddon, D., Harding, S. P., (2017). Individualised variable-interval risk-based screening for sight-threatening diabetic retinopathy: The Liverpool Risk Calculation Engine. Diabetologia, 60(11), 2174–2182. https://doi.org/10.1007/s00125-017-4386-0
Farquhar, N., Thornton, S., Coupland, S. E., Coulson, J. M., Sacco, J. J., Krishna, Y., Heimann, H., Taktak, A., Cebulla, C. M., Abdel‐Rahman, M. H., & Kalirai, H. (2017). Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma. The Journal of Pathology: Clinical Research, 4(1), 26–38. https://doi.org/10.1002/cjp2.86
Cubbon, R. M., Ruff, N., Groves, D., Eleuteri, A., Denby, C., Kearney, L., Ali, N., Walker, A. M. N., Jamil, H., Gierula, J., Gale, C. P., Batin, P. D., Nolan, J., Shah, A. M., Fox, K. A. A., Sapsford, R. J., Witte, K. K., & Kearney, M. T. (2016). Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart (British Cardiac Society), 102(3), 223–229. https://doi.org/10.1136/heartjnl-2015-308428
DeParis, S. W., Taktak, A., Eleuteri, A., Enanoria, W., Heimann, H., Coupland, S. E., & Damato, B. (2016). External Validation of the Liverpool Uveal Melanoma Prognosticator Online. Investigative Ophthalmology & Visual Science, 57(14), 6116–6122. https://doi.org/10.1167/iovs.16-19654
Grixti, A., Hagan, R., Nayak, H., & Chandna, A. (2016). Multifocal choroiditis with panuveitis in an 8-year-old boy with long-standing idiopathic acute anterior uveitis. European Journal of Ophthalmology, 26(5), e114-117. https://doi.org/10.5301/ejo.5000772
Medcalf, J. E., Paul Johnson, C., Taktak, A., & Grabherr, S. (2016). Variations in the anatomy of the vertebral artery cervical loop segment—A potential predisposing factor for traumatic basal subarachnoid hemorrhage? Forensic Science, Medicine, and Pathology, 12(4), 444–450. https://doi.org/10.1007/s12024-016-9819-4
Walker, A. M., Patel, P. A., Rajwani, A., Groves, D., Denby, C., Kearney, L., Sapsford, R. J., Witte, K. K., Kearney, M. T., & Cubbon, R. M. (2016). Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction. Diabetes & Vascular Disease Research, 13(5), 331–340. https://doi.org/10.1177/1479164116653342
Caines, R., Eleuteri, A., Kalirai, H., Fisher, A. C., Heimann, H., Damato, B. E., Coupland, S. E., & Taktak, A. F. G. (2015). Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma. Molecular Vision, 21, 1–11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316690/
Denby, C., Groves, D. G., Eleuteri, A., Tsang, H. K., Leach, A., Hammond, C., Bridson, J. D., Fisher, M., Elt, M., Laflin, R., & Fisher, A. C. (2015). Temporary sympathectomy in chronic refractory angina: A randomised, double-blind, placebo-controlled trial. British Journal of Pain, 9(3), 142–148. https://doi.org/10.1177/2049463714549775
Middle, S., Coupland, S. E., Taktak, A., Kidgell, V., Slupsky, J. R., Pettitt, A. R., & Till, K. J. (2015). Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin’s lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins. Experimental Hematology & Oncology, 4, 10. https://doi.org/10.1186/s40164-015-0004-3
Broadbent, D. M., Harding, S. P., Garcia-Finana, M., Fisher, A. C., Bennett, A., Appelbe, D. E., & Wang, A., (2015) Introducing personalised risk based intervals in screening for diabetic retinopathy: the ISDR study. European Journal of Ophthalmology, 25(3), E20-E21.
Galarza, M., Isaac, C., Pellicer, O., Mayes, A., Broks, P., Montaldi, D., Denby, C., & Simeone, F. (2014). Jazz, guitar, and neurosurgery: The Pat Martino case report. World Neurosurgery, 81(3–4), 651.e1-7. https://doi.org/10.1016/j.wneu.2013.09.042
Praidou, A., Hagan, R., Nayak, H., & Chandna, A. (2014). Multifocal electroretinogram contributes to differentiation of various clinical pictures within a family with Bardet-Biedl syndrome. Eye (London, England), 28(9), 1136–1142. https://doi.org/10.1038/eye.2014.150
Taktak, P. Ganney, D. Long, P. White (2013) Clinical Engineering: A Handbook for Clinical and Biomedical Engineers(1st ed.), Elsevier, ISBN: 9780123972385
Ferm, I., Lightfoot, G., & Stevens, J. (2013). Comparison of ABR response amplitude, test time, and estimation of hearing threshold using frequency specific chirp and tone pip stimuli in newborns. International Journal of Audiology, 52(6), 419–423. https://doi.org/10.3109/14992027.2013.769280
Lake, S. L., Damato, B. E., Kalirai, H., Dodson, A. R., Taktak, A. F. G., Lloyd, B. H., & Coupland, S. E. (2013). Single Nucleotide Polymorphism Array Analysis of Uveal Melanomas Reveals That Amplification of CNKSR3 Is Correlated With Improved Patient Survival. The American Journal of Pathology, 182(3), 678–687. https://doi.org/10.1016/j.ajpath.2012.11.036
Praidou, A., Hagan, R., Newman, W., & Chandna, A. (2013). Early diagnosis of Stargardt disease with multifocal electroretinogram in children. International Ophthalmology, 34(3), 613–621. https://doi.org/10.1007/s10792-013-9812-9
Eleuteri, A., Damato, B., Coupland, S. E., & Taktak, A. F. G. (2012). Enhancing survival prognostication in patients with choroidal melanoma by integrating pathologic, clinical and genetic predictors of metastasis. International Journal of Biomedical Engineering and Technology, 8(1), 18. https://doi.org/10.1504/IJBET.2012.045355
Eleuteri, A., & Taktak, A. F. G. (2012). Support Vector Machines for Survival Regression. In E. Biganzoli, A. Vellido, F. Ambrogi, & R. Tagliaferri (Eds.), Computational Intelligence Methods for Bioinformatics and Biostatistics (pp. 176–189). Springer. https://doi.org/10.1007/978-3-642-35686-5_15
Fisher, A. C., Eleuteri, A., Groves, D., & Dewhurst, C. J. (2012). The Ornstein-Uhlenbeck third-order Gaussian process (OUGP) applied directly to the un-resampled heart rate variability (HRV) tachogram for detrending and low-pass filtering. Medical & Biological Engineering & Computing, 50(7), 737–742. https://doi.org/10.1007/s11517-012-0928-2
Idowu, O. K., Ding, Q., Taktak, A. F. G., Chandrasekar, C. R., & Yin, Q. (2012). Clinical implication of pretreatment neutrophil to lymphocyte ratio in soft tissue sarcoma. Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 17(6), 539–544. https://doi.org/10.3109/1354750X.2012.699554
Jmor, F., Kalirai, H., Taktak, A., Damato, B., & Coupland, S. E. (2012). HSP-27 protein expression in uveal melanoma: Correlation with predicted survival. Acta Ophthalmologica, 90(6), 534–539. https://doi.org/10.1111/j.1755-3768.2010.02038.x
Neary, W., & Lightfoot, G. (2012). Auditory neuropathy spectrum disorder: Examples of poor progress following cochlear implantation. Audiological Medicine, 10(3), 143–150. https://doi.org/10.3109/1651386X.2012.707352
Angi, M., Damato, B., Kalirai, H., Dodson, A., Taktak, A., & Coupland, S. E. (2011). Immunohistochemical assessment of mitotic count in uveal melanoma. Acta Ophthalmologica, 89(2), e155-160. https://doi.org/10.1111/j.1755-3768.2009.01769.x
Campa, C., Hagan, R., Sahni, J. N., Brown, M. C., Beare, N. A. V., Heimann, H., & Harding, S. P. (2011). Early multifocal electroretinogram findings during intravitreal ranibizumab treatment for neovascular age-related macular degeneration. Investigative Ophthalmology & Visual Science, 52(6), 3446–3451. https://doi.org/10.1167/iovs.10-6588
Damato, B., Eleuteri, A., Taktak, A. F. G., & Coupland, S. E. (2011). Estimating prognosis for survival after treatment of choroidal melanoma. Progress in Retinal and Eye Research, 30(5), 285–295. https://doi.org/10.1016/j.preteyeres.2011.05.003
Hagan, R. P., Fisher, A. C., & Brown, M. C. (2011). Investigation of the temporal properties of the retina using the m-sequence. Documenta Ophthalmologica. Advances in Ophthalmology, 123(3), 179–185. https://doi.org/10.1007/s10633-011-9295-9
Harigopal, S., Satish, H. P., Taktak, A. F. G., Southern, K. W., & Shaw, N. J. (2011). Oxygen saturation profile in healthy preterm infants. Archives of Disease in Childhood. Fetal and Neonatal Edition, 96(5), F339-342. https://doi.org/10.1136/adc.2010.191437
Lake, S. L., Damato, B. E., Dopierala, J., Baudo, M. M., Taktak, A. F. G., & Coupland, S. E. (2011). Multiplex Ligation-Dependent Probe Amplification Analysis of Uveal Melanoma with Extraocular Extension Demonstrates Heterogeneity of Gross Chromosomal Abnormalities. Investigative Ophthalmology & Visual Science, 52(8), 5559–5564. https://doi.org/10.1167/iovs.10-6845
Lake, S. L., Jmor, F., Dopierala, J., Taktak, A. F. G., Coupland, S. E., & Damato, B. E. (2011). Multiplex ligation-dependent probe amplification of conjunctival melanoma reveals common BRAF V600E gene mutation and gene copy number changes. Investigative Ophthalmology & Visual Science, 52(8), 5598–5604. https://doi.org/10.1167/iovs.10-6934
Saeed, M. U., Noonan, C., Hagan, R., & Brown, M. (2011). Relatively spared central multifocal electroretinogram responses in acute quinine toxicity. BMJ Case Reports, 2011. https://doi.org/10.1136/bcr.04.2011.4166
Dopierala, J., Damato, B. E., Lake, S. L., Taktak, A. F. G., & Coupland, S. E. (2010). Genetic Heterogeneity in Uveal Melanoma Assessed by Multiplex Ligation-Dependent Probe Amplification. Investigative Ophthalmology & Visual Science, 51(10), 4898–4905. https://doi.org/10.1167/iovs.09-5004
Fisher, A. C., Lake, S. P., Cunningham, I. P., & Chandna, A. (2010). Web-StrabNet: A Web-Based Expert System for the Differential Diagnosis of Vertical Strabismus (Squint). Computational and Mathematical Methods in Medicine, 11(1), 89–97. https://livrepository.liverpool.ac.uk/2034234/
Hagan, R. P., Small, A., Fisher, A. C., & Brown, M. C. (2010). Can central hexagon peak latency provide a clue to fixation within the mfERG. Documenta Ophthalmologica. Advances in Ophthalmology, 120(2), 159–164. https://doi.org/10.1007/s10633-009-9206-5
Lake, S. L., Coupland, S. E., Taktak, A. F. G., & Damato, B. E. (2010). Whole-Genome Microarray Detects Deletions and Loss of Heterozygosity of Chromosome 3 Occurring Exclusively in Metastasizing Uveal Melanoma. Investigative Ophthalmology & Visual Science, 51(10), 4884–4891. https://doi.org/10.1167/iovs.09-5083
Naguib, R., & Taktak, A. (2010). Editorial, Special Issue on Decision Support Systems in Healthcare. International Journal of Biomedical Engineering and Technology, 3, 209–211.
Raja, V., Kumar, A., Durnian, J., Hagan, R., Buxton, N., & Newman, W. (2010). The role of visually evoked potentials in the management of hemispheric arachnoid cyst compressing the posterior visual pathways. Journal of AAPOS: The Official Publication of the American Association for Pediatric Ophthalmology and Strabismus, 14(1), 85–87. https://doi.org/10.1016/j.jaapos.2009.10.010
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